This study was designed to investigate the relationship of immune function in schizophrenia focusing on number & percentage of T & B lymphocytes.
The subjects consist of 44 male schizophrenics by DSM-III-R who admitted to the Department of Neuropsychiatry, College of Medicine, Korea University and Samyoung Mental Hospital from March 1, 1989 to May 31, 1990. The 18 normal controls were
healthy
volunteers and were selected age matching to schizophrenic patients.
@ES The results were as follows:
@EN 1) There were statistically significant differences between and controls and naive or drug-wash out schizophrenics in percentage of B lymphocyte and T8 Cell(P<0.05).
2) There were statistically significant differences among normal controls below 2 years durations chronic schizophrenics, above 2 below 5 years durations schizophrenics and more than 5years durations chronic schizophrenics in number of T
lymphocyte,
percentage of B lymphocyte, number of T8 cell and T4/T8 ratio(p<0.05).
3) There were statistically significant differences among normal controls, schizophrenics with positive symptoms and schizophrenics with negative symptoms in percentage of T lymphocyte or B lymphocyte or number of T8 cells or T4/T8
ratio(p<0.05).
4) There were no significant differences on the basis of administrative antipsychotics durations in lymphocyte pupulations(P<0.05).
5) There were statistically significant differences on the basis of dosage of administrative antipsychotics in T4/T8 ratio(p<0.05).
6) There were no significant differences on the basis of description of administrative antipsychotics(P>0.05).
7) There were statistically significant differences between admitted schizophrenic patients and ambulatory schizophrenic patients in percentage of T lymphocyte, number of T8 cells(P<0.05) and number & percentage of B lymphocyte(P<0.001).
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